Usually, not by lifting one by the frame as the man is doing in the photo. Unless the string, cord, wire or chain at the back is loose, frayed or damaged and unless the retaining hangers or fixings are missing or loose, picture frames and photo frames ought always be carried by whatever hanging devices they were fitted with. That's why they're there for. The danger with carrying picture frames by their frames .. especially larger frames, is that doing this might break the framing tape seal, "spring" open the backing, upset the picture frame assembly and pop out the backing board, or, heaven forbid, move the glass out of the frame. This isn't an exaggeration. We've actually seen this happen a few times over the years, causing varying degrees of customer ... heartache. That said, there are picture framers who specifically advise the opposite, and that is, never to carry picture frames by their hanging devices. Doing so, they say, places unreasonable stress on the fixings and these may fail as a consequences. We disagree. If this happens, then the picture framer has made a faulty picture frame. And it's better that this be discovered while carrying it rather than have it crash down while high on a house wall and possibly inuring someone. And seeing as you're reading about carrying picture frames, it might also interest you to read about hanging them, if so see our Picture Frames Hanging page.